Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS), lactase deficiency, nephrolithisasis and thyroid diseases are considered endemic. The aim of our study was to evaluate which of the above-mentioned diseases affect the most the bone metabolic parameters, bone mineral density (BMD) and the prevalence of bone fractures in fertile aged women.Materials and methods: A total of 92 fertile aged women (32.6±5.2 years) were divided into four groups (23 in each)...

Introduction: Over the past few years the clinical relevance of serum uric acid level has changed. The elevated serum uric acid level not only impairs the joints and the kidney function but it is also linked with an increased risk of cardivascular diseases. The aim of our study was to examine how bones are affected (change of bone mineral density (BMD), bone metabolism parameters, serum 25-hydroxyvitamin D levels and frequency of fractures) by elevated serum uric acid level.</...

Introduction: Lactose intolerance itself is linked with lower peak bone mass (PBM) and with decreased bone mineral density (BMD) which may decrease further with lactose intolerance associated comorbidities. The aim of our study was to examine how bone metabolic parameters are affected (change of bone metabolism markers, BMD and frequency of fractures) in lactose intolerance which was accompanied by previously diagnosed hyperlipidemia or by hypothyroidism.<p class="abstext"...

A 32-year-old women initially presented with recurrent kidney stones and was found to have nephrocalcinosis. She was found to normocalcaemic but hypercalciuric, with a plasma ionized calcium at upper-limit of normal and a PTH in lower normal range. One year later, during the first trimester of a pregnancy, she presented with severe hypercalcaemia, hypercalciuria and suppression of PTH. Extensive investigations for causes of hypercalcaemia excluded hyperparathyroidism, other en...

Introduction: Altered sensitivity against glucocorticoids is partly influenced by polymorphisms (SNP) of the glucocorticoid receptor gene (GR). The aim of the present study was to extend our earlier study by inclusion and evaluation the role of the BclI and A3669G polymorphisms of the GR in patients with hormonally inactive adrenal adenomas.Description of methods: This is a retrospective, single-centre genetic association study The study included 99 pati...